Cat genes could hold the key to future cancer treatments

Although we adore our feline friends, it does not often seem like we have much in common with them — unless, of course, you also have a passion for attacking furniture legs and licking your own rear. When it comes to health, however, cats are exposed to many of the same environmental risks as their owners and they fall victim to many of the same ailments. Cancer, for example, is one of the leading causes of illness and death in cats; however, the genetics of this disease in felines remain relatively unexplored.

Pigs and grizzlies, not monkeys, hold clues to youthful human skin

Research with pigs and grizzly bears showed that key skin structures called rete ridges, which help keep human skin strong and elastic, form after birth rather than during fetal development. The study, published in Nature, identified bone morphogenetic protein signaling as a key pathway and provides a concrete molecular target for therapies for wound healing, scar repair and age-related skin thinning.

New paper urges caution as FDA plans to phase out animal testing in drug development

FDA’s animal testing phaseout needs caution, experts say: Biomedical research with animals remains essential for preclinical safety testing, and rapidly replacing animal studies with unvalidated alternatives could increase the risk of unsafe or ineffective drugs reaching patients, legal expert Sara Gerke and colleagues wrote in Trends in Biotechnology. The Authors recommend maintaining animal testing alongside alternatives until enough data proves equivalence, and they propose measures like premarket reviews or independent certification to ensure the safety and efficacy of new methods.