Smart Pads Detect Disease Biomarkers in Period Blood:  Sensors embedded in sanitary napkins screen menstrual effluent, offering an accessible, non-invasive tool to monitor health

Smart menstrual pads have potential to detect disease biomarkers: Inge Herrmann and researchers in her lab at ETH Zurich have developed MenstruAI, a menstrual pad embedded with test strips that change color when they come into contact with specific disease biomarkers in menstrual blood. The researchers also developed a companion smartphone app that analyzes an image of the pad before it is discarded.

The mini placentas and ovaries revealing the basics of women’s health:  Lab-made organoids that mimic reproductive tissues could point to treatments for common conditions such as pre-eclampsia and endometriosis

Women create organoids to study reproductive health: Scientists Ashley Moffett, Margherita Turco, Linda Griffith, Mirjana Kessler, and Victoria Roberts are among the women leading research on women’s reproductive health, creating organoids of the reproductive system to understand normal biology and disease. The researchers have created models of the placenta, ovary, endometrium and vagina to learn more about pre-eclampsia, menstruation and endometriosis.

The brain fires up immune cells when sick people are nearby:  When people viewed virtual avatars with coughs or rashes, their brains triggered an immune response.

Brain triggers immune response at sight of illness: Seeing virtual representations of people with signs of illness, such as coughs or rashes, activates brain regions linked to personal space and triggers an innate immune response that mimics the body’s response to a real infection. This brain-driven immune activation suggests potential uses of virtual reality to boost vaccine responses by priming the immune system before exposure, researchers reported in Nature Neuroscience.

World’s first AI-designed viruses a step towards AI-generated life:  Scientists used artificial intelligence to write coherent viral genomes, using them to synthesize bacteriophages capable of killing resistant strains of bacteria.

AI-designed viruses target antibiotic-resistant bacteria: Scientists at Stanford University have created the first AI-designed viruses capable of targeting and killing E. coli bacteria. This breakthrough, detailed in a preprint on bioRxiv, demonstrates AI’s potential in designing biotechnological tools and therapies. Using AI models Evo 1 and Evo 2, the researchers generated viral genomes that successfully infected antibiotic-resistant E. coli strains, showcasing a promising advancement for phage therapy. However, the study also raises biosafety concerns as the technology progresses toward AI-generated life.

Biofilm Bacteria May Fuel Heart Attacks:  Evidence from autopsies and surgical patients suggested that oral bacteria can infiltrate hardened arteries and trigger immune responses tied to heart attacks

Oral bacteria linked to heart attack risk: DNA from oral bacteria was found in a significant portion of arterial plaques from sudden death victims and surgical patients, and when activated by external triggers, these bacteria may provoke immune responses that contribute to plaque rupture and the onset of myocardial infarction, according to a study in the Journal of the American Heart Association. The findings highlight both the potential for biofilm-targeted therapies to prevent heart attacks and the importance of oral hygiene in cardiovascular health.

From heart to skin to hair, ‘Replaceable You’ dives into the science of transplant

From pig organs to 3D printing: The future of transplants – Science writer Mary Roach’s latest book, “Replaceable You: Adventures in Human Anatomy,” explores the history and future of replacing human body parts, from 16th-century prosthetic noses to modern advances in gene editing and 3D-printed tissue. Roach traces how pigs became the standard model for organ transplants, why genetic editing is crucial to reduce rejection and how scientists are working to print muscle that mimics natural structures.

Inflammation During Pregnancy May Prime Offspring for Anxiety

Mouse study shows that maternal inflammation linked to long-term anxiety risk in offspring: A study with mice showed that that prenatal inflammation or stress during pregnancy can trigger epigenetic changes in specific neurons in the offspring’s hippocampus, leaving them primed for anxiety-like behaviors in adulthood. Researchers say these findings link prenatal adversity to lasting brain changes and may guide the search for early biomarkers and new treatments.

Women’s healthcare chronically underfunded, say Melinda French Gates

Melinda French Gates pledges another $50M for women’s health: Melinda French Gates has committed an additional $50 million to women’s health research through Pivotal Ventures and Wellcome Leap. The funding will be used to address areas such as autoimmune conditions, cardiovascular disease, and mental health. “Women’s health is chronically underfunded, chronically under-researched, and, as a result, not well understood,” French Gates said.

Amphetamine users get higher with a little help from microbial friends

Amphetamines can be extremely helpful for people with certain neuropsychiatric conditions, such as ADHD. However, they are also frequently misused and abused, creating a growing public health problem. There are currently no medicines for treating amphetamine use disorder, but hope may be on the horizon: Researchers have zeroed in on how a common microbe enhances the effects of these drugs — which means they might someday be able to do the opposite.