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Microbes in Baboon Poop Offer Clues into Aging:  Microbiome clocks based on patterns in baboons’ gut microbes reflect demographic and socio-environmental factors, providing insights into aging

Wild baboon microbiome offers clues to healthy aging: Researchers working with wild baboons in East Africa used microbiome data from fecal samples to develop a gut-based biological aging clock, which they used to predict chronological age with an error rate of two (2) years, outperforming human-based versions. This animal model revealed that age-related shifts in microbial diversity are influenced by sex, social status, and environmental conditions, and the findings, reported in eLife, may help scientists better understand how manipulating the microbiome can promote healthy aging in humans.

Can Peanut Allergies be Cured? – Remarkable new treatments can free millions of kids and adults from the deadly threat of peanut allergy, tackling one of our fastest-growing medical problems

Peanut allergies and the search for a cure: Peanut allergies, once rare, have become a major public health challenge since the 1990s, affecting millions of children and adults and reshaping daily life in schools and homes. The causes remain unclear, with theories pointing to overly clean environments, genetics and delayed childhood exposure. A true cure is not yet available; however, new therapies such as oral immunotherapy, skin patches, biologic drugs like Xolair, immune resetting regimens and early peanut introduction in infants offer families real hope for safety and a future with fewer restrictions.

The Supreme Court allows Trump to cut research funding

The Supreme Court has ruled that the Trump administration can proceed with cutting $783 million in research funding as part of its efforts to reduce federal diversity, equity and inclusion initiatives. The decision, made by a 5-4 vote, lifts a previous block on these cuts, although future funding cuts under the same directive remain blocked. The ruling has sparked criticism from Democratic state attorneys general and public health groups, who argue that it disrupts scientific research and potential breakthroughs. The Justice Department supports the cuts, arguing that funding decisions should not be subject to judicial review.

Taylor Swift Talks Medtech

MD+DI (Medical Device and Diagnostic Industry) Senior Editor Point of View (POV) geeks out over the pop star’s MedTech comments during Swift’s recent appearance on the New Heights podcast

Apple snails regrow their eyes – and may help humans do the same:  Human eyes are masterpieces of biological engineering; however, once damaged, they cannot rebuild themselves.  Golden apple snails, by contrast, routinely replace an entire camera-type eye within a month.

Apple snail’s eye regeneration could aid human therapy: A study in Nature Communications has found that golden apple snails have the ability to regrow their eyes, in a process that shares anatomical and genetic similarities with humans. Researchers using CRISPR-Cas9 to study gene function during regeneration found that genes such as pax6 are crucial for eye development. The research could lead to therapies for vision loss in humans by activating dormant regenerative genes.

This Physician-Scientist Is Taking on Trump on Behalf of Disadvantaged Communities

Researcher challenges grant cuts: Pulmonologist Neeta Thakur, a Researcher at the University of California, San Francisco, is leading a legal challenge against the federal government’s suspension of grants for research deemed to have a diversity, equity, and inclusion component. Thakur’s research on wildfire smoke and its impacts on underserved communities was disrupted by the funding cuts; however, she won a preliminary injunction and the grants were temporarily reinstated.

Trump’s autism initiative embraces little-tested vitamin as a treatment:  FDA to approve leucovorin despite questions about whom it might help

Trump’s autism initiative touts a little-tested vitamin as treatment: As part of a highly anticipated announcement in which U.S. President Donald Trump outlined his administration’s approach to what he called the “crisis of autism,” federal officials said the Food and Drug Administration (FDA) would approve a drug called leucovorin, a form of folate, as “the first FDA-recognized treatment pathway for autism” — an unusual move for a pill only tested in a few small studies.

Immune-dodging cells could give diabetes treatment a shot in the arm:  In first human test, genetically modified pancreas cells injected into patient’s arm evade immune attack, produce insulin

First patient gets CRISPR-edited insulin cells in diabetes trial: A Swedish man with type 1 diabetes became the first person to receive CRISPR-edited pancreatic cells that produce insulin while avoiding immune rejection, allowing the cells to survive for at least three (3) months without the need for immunosuppressive drugs, according to a study in The New England Journal of Medicine. Developed by Sana Biotechnology, these cells had key immune-stimulating proteins removed and were enhanced with a protective protein, CD47, using CRISPR technology.