Combating Alzheimer’s by restoring the brain’s cleanup crew
August 08, 2019 Now, using CRISPR-Cas9 knockout screens and RNA sequencing, a Stanford University team of scientists has identified CD22 — a B-cell receptor that keeps immune responses in check — as a negative controller of microglial phagocytosis. Tuning down CD22 appears to improve cognitive function in aged mice. The researchers reported their findings in … Read more